The Protein Trinity: Structure/Function Relationships That Include Intrinsic Disorder
نویسندگان
چکیده
منابع مشابه
Intrinsic Protein Disorder and Protein-Protein Interactions
Intrinsically disordered proteins often bind to more than one partner. In this study, we focused on 11 sets of complexes in which the same disordered segment becomes bound to two or more distinct partners. For this collection of protein complexes, two or more partners of each disordered segment were selected to have less than 25% amino acid identity at structurally aligned positions. As it tur...
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2 The dominant view of protein structure-function is that an amino acid sequence specifies a (mostly) fixed three-dimensional (3-D) structure that is a prerequisite to protein function. In contrast to the dominant view, many proteins display functions requiring the disordered state. Our purpose here is to provide a catalogue of disorder-function relationships. The very important molecular detai...
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The standard view is that each protein’s amino acid sequence provides the information for it to fold into a specific 3D structure, and the active site formed within this structure enables function. Indeed, current biology and biochemical textbooks suggest that virtually all proteins act via this sequence-to-structure-to-function paradigm. These views are correct for enzymes, which function as c...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2002
ISSN: 1537-744X
DOI: 10.1100/tsw.2002.25